Quantitative Phosphoproteomics Reveals a Role for Collapsin Response Mediator Protein 2 in PDGF-Induced Cell Migration

Abstract The Platelet Derived Growth Factor (PDGF) family of ligands have well established functions in the induction of cell proliferation and migration during development, tissue homeostasis and interactions between tumours and stroma.However, the mechanisms by which leather-strapon these actions are executed are incompletely understood.Here we r

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Population-based cancer screening through community participation: Outcome of a district wide oral cancer screening program from rural Kannur, Kerala, India

Background: Oral cancer is a major public health challenge, and about one-fifth of all oral cancer cases reported globally are from India.In spite of the potential for early detection by simple visual examination, the majority of patients report in later stages of the disease, especially in Drain Outlet Hose Extension low and middle-income countrie

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Electrical stimulation of chicken embryo development supports the Inside story scenario of human development and evolution

Abstract Animal evolution is driven by random mutations at the genome level.However, it has long been suggested that there exist physical constraints which limit the set of possible outcomes.In craniate evolution, it has been observed that head features, notably in the genus homo, can be ordered in a morphological diagram such that, as the brain ex

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An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Membrane contact sites are regions of close apposition between organelles that facilitate information transfer.Here, we Chase Rack reveal an essential role for Ca2+ derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic reticulum (ER).Antagonizing action of the Ca2+-mobilizing messenger NAADP, inhibiting

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